Without a doubt Radio Lab is my favorite podcast. It’s an endless source of inspiration for me. Here’s what they have to say about themselves (from their site):

Radiolab believes your ears are a portal to another world. Where sound illuminates ideas, and the boundaries blur between science, philosophy, and human experience. Big questions are investigated, tinkered with, and encouraged to grow. Bring your curiosity, and we’ll feed it with possibility.

Check it out:

www.radiolab.org